Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets

BACKGROUND: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate target gene dosage with cellular phenotypes. This however requires a set of RNAi...

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Detalhes bibliográficos
Main Authors: Micklem, David R, Blø, Magnus, Bergström, Petra, Hodneland, Erlend, Tiron, Crina, Høiby, Torill, Gjerdrum, Christine, Hammarsten, Ola, Lorens, James B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074332/
https://ncbi.nlm.nih.gov/pubmed/24952598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-57
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