Host Competence and Helicase Activity Differences Exhibited by West Nile Viral Variants Expressing NS3-249 Amino Acid Polymorphisms

A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs) following West Nile virus (WNV) infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority...

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Главные авторы: Langevin, Stanley A., Bowen, Richard A., Reisen, William K., Andrade, Christy C., Ramey, Wanichaya N., Maharaj, Payal D., Anishchenko, Michael, Kenney, Joan L., Duggal, Nisha K., Romo, Hannah, Bera, Aloke Kumar, Sanders, Todd A., Bosco-Lauth, Angela, Smith, Janet L., Kuhn, Richard, Brault, Aaron C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074097/
https://ncbi.nlm.nih.gov/pubmed/24971589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100802
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