Host Competence and Helicase Activity Differences Exhibited by West Nile Viral Variants Expressing NS3-249 Amino Acid Polymorphisms

A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs) following West Nile virus (WNV) infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority...

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Detalhes bibliográficos
Main Authors: Langevin, Stanley A., Bowen, Richard A., Reisen, William K., Andrade, Christy C., Ramey, Wanichaya N., Maharaj, Payal D., Anishchenko, Michael, Kenney, Joan L., Duggal, Nisha K., Romo, Hannah, Bera, Aloke Kumar, Sanders, Todd A., Bosco-Lauth, Angela, Smith, Janet L., Kuhn, Richard, Brault, Aaron C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074097/
https://ncbi.nlm.nih.gov/pubmed/24971589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100802
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