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Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers in C. elegans

Like mammalian neurons, C. elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in AVM axon regeneration. In older AVM axons, let-7 inhibits regeneration by down regulating LIN-41, an important AVM axon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zou, Yan, Chiu, Hui, Zinovyeva, Anna, Ambros, Victor, Chuang, Chiou-Fen, Chang, Chieh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074024/
https://ncbi.nlm.nih.gov/pubmed/23599497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231321
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