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Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers in C. elegans
Like mammalian neurons, C. elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in AVM axon regeneration. In older AVM axons, let-7 inhibits regeneration by down regulating LIN-41, an important AVM axon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074024/ https://ncbi.nlm.nih.gov/pubmed/23599497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231321 |
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