Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells

The innate immune response to bacterial infection is mediated through Toll-like receptors (TLRs), which trigger tightly regulated signaling cascades through transcription factors including NF-κB. LPS activation of TLR4 triggers internalization of the receptor-ligand complex which is directed toward...

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Hlavní autoři: Kelly, Catriona, Canning, Paul, Buchanan, Paul J., Williams, Mark T., Brown, Vanessa, Gruenert, Dieter C., Elborn, J. Stuart, Ennis, Madeleine, Schock, Bettina C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073939/
https://ncbi.nlm.nih.gov/pubmed/23316065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00372.2011
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