Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE)

In recent years it has become clear that, mechanistically, biomineralization is a process that has to be actively inhibited as a default state. This inhibition must be released in a rigidly controlled manner in order for mineralization to occur in skeletal elements and teeth. A central aspect of thi...

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Bibliographic Details
Main Authors: Apschner, Alexander, Huitema, Leonie F. A., Ponsioen, Bas, Peterson-Maduro, Josi, Schulte-Merker, Stefan
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073271/
https://ncbi.nlm.nih.gov/pubmed/24906371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.015693
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