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Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFβ-dependent biological outputs such as epithelial-mesenchymal transition (EMT). Here, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two...

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Detalhes bibliográficos
Main Authors: Soond, Surinder M., Chantry, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073228/
https://ncbi.nlm.nih.gov/pubmed/21258410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.617
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