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Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFβ-dependent biological outputs such as epithelial-mesenchymal transition (EMT). Here, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073228/ https://ncbi.nlm.nih.gov/pubmed/21258410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.617 |
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