Contribution of genetic variation to transgenerational inheritance of DNA methylation

BACKGROUND: Despite the important role DNA methylation plays in transcriptional regulation, the transgenerational inheritance of DNA methylation is not well understood. The genetic heritability of DNA methylation has been estimated using twin pairs, although concern has been expressed whether the un...

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Main Authors: McRae, Allan F, Powell, Joseph E, Henders, Anjali K, Bowdler, Lisa, Hemani, Gibran, Shah, Sonia, Painter, Jodie N, Martin, Nicholas G, Visscher, Peter M, Montgomery, Grant W
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072933/
https://ncbi.nlm.nih.gov/pubmed/24887635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-5-r73
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