Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice

Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (Mecp2) cause most cases of Rett syndrome (RTT). Currently there is no cure for RTT. Abnormal EEGs are found in 100% of RTT cases and are associated with severe sleep dysfunction, the cause of which is not well understood. Mice def...

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Bibliografski detalji
Glavni autori: Johnston, Michael V., Ammanuel, Simon, O'Driscoll, Cliona, Wozniak, Amy, Naidu, Sakkubai, Kadam, Shilpa D.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2014
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072927/
https://ncbi.nlm.nih.gov/pubmed/25018705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsys.2014.00118
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