In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study

BACKGROUND: Increased antibiotic resistance against Staphylococcus aureus and low penetration into bone requires regimen optimization of available drugs. METHODS: We evaluate pharmoacokinetic and pharmacodynamic parameters (PK/PD) as well as in vivo interactions of continuous flucloxacillin 12 g/d a...

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Main Authors: Garzoni, Christian, Uçkay, Ilker, Belaieff, Wilson, Breilh, Dominique, Suvà, Domizio, Huggler, Elzbieta, Lew, Daniel, Hoffmeyer, Pierre, Bernard, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072877/
https://ncbi.nlm.nih.gov/pubmed/25019039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-3-287
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