Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly

Here we demonstrate that Arp2/3 regulates a transition between mesenchymal and amoeboid protrusions in MCF10A epithelial cells. Using genetic and pharmacological means, we first show Arp2/3 inhibition impairs directed cell migration. Arp2/3 inhibition results in a dramatically impaired cell adhesion...

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Detalhes bibliográficos
Main Authors: Beckham, Yvonne, Vasquez, Robert J., Stricker, Jonathan, Sayegh, Kareem, Campillo, Clement, Gardel, Margaret L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072770/
https://ncbi.nlm.nih.gov/pubmed/24967897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100943
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