Abnormal Type I Collagen Post-translational Modification and Crosslinking in a Cyclophilin B KO Mouse Model of Recessive Osteogenesis Imperfecta

Cyclophilin B (CyPB), encoded by PPIB, is an ER-resident peptidyl-prolyl cis-trans isomerase (PPIase) that functions independently and as a component of the collagen prolyl 3-hydroxylation complex. CyPB is proposed to be the major PPIase catalyzing the rate-limiting step in collagen folding. Mutatio...

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Main Authors: Cabral, Wayne A., Perdivara, Irina, Weis, MaryAnn, Terajima, Masahiko, Blissett, Angela R., Chang, Weizhong, Perosky, Joseph E., Makareeva, Elena N., Mertz, Edward L., Leikin, Sergey, Tomer, Kenneth B., Kozloff, Kenneth M., Eyre, David R., Yamauchi, Mitsuo, Marini, Joan C.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072593/
https://ncbi.nlm.nih.gov/pubmed/24968150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004465
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