Accurate Dereplication of Bioactive Secondary Metabolites from Marine-Derived Fungi by UHPLC-DAD-QTOFMS and a MS/HRMS Library

In drug discovery, reliable and fast dereplication of known compounds is essential for identification of novel bioactive compounds. Here, we show an integrated approach using ultra-high performance liquid chromatography-diode array detection-quadrupole time of flight mass spectrometry (UHPLC-DAD-QTO...

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Main Authors: Kildgaard, Sara, Mansson, Maria, Dosen, Ina, Klitgaard, Andreas, Frisvad, Jens C., Larsen, Thomas O., Nielsen, Kristian F.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071597/
https://ncbi.nlm.nih.gov/pubmed/24955556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12063681
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