Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

In atherosclerosis, plaques preferentially develop in arterial regions of disturbed blood flow (d-flow), which alters endothelial gene expression and function. Here, we determined that d-flow regulates genome-wide DNA methylation patterns in a DNA methyltransferase–dependent (DNMT-dependent) manner....

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Detalhes bibliográficos
Main Authors: Dunn, Jessilyn, Qiu, Haiwei, Kim, Soyeon, Jjingo, Daudi, Hoffman, Ryan, Kim, Chan Woo, Jang, Inhwan, Son, Dong Ju, Kim, Daniel, Pan, Chenyi, Fan, Yuhong, Jordan, I. King, Jo, Hanjoong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071393/
https://ncbi.nlm.nih.gov/pubmed/24865430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74792
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