Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

BACKGROUND. Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation of ex vivo–expanded UCB shortens time to hematopoietic recovery, but long-term, robust engraftment by the expanded unit has yet to be demonstrated. We tested the hypothesis t...

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Hauptverfasser: Horwitz, Mitchell E., Chao, Nelson J., Rizzieri, David A., Long, Gwynn D., Sullivan, Keith M., Gasparetto, Cristina, Chute, John P., Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Galamidi, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071379/
https://ncbi.nlm.nih.gov/pubmed/24911148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74556
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