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RNA-seq: impact of RNA degradation on transcript quantification

BACKGROUND: The use of low quality RNA samples in whole-genome gene expression profiling remains controversial. It is unclear if transcript degradation in low quality RNA samples occurs uniformly, in which case the effects of degradation can be corrected via data normalization, or whether different...

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Bibliografiske detaljer
Main Authors: Gallego Romero, Irene, Pai, Athma A, Tung, Jenny, Gilad, Yoav
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071332/
https://ncbi.nlm.nih.gov/pubmed/24885439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-12-42
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