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Focal gains of VEGFA: candidate predictors of sorafenib response in Hepatocellular Carcinoma
Focal amplifications in 6p21 containing the VEGFA locus occur in 7-10% of hepatocellular carcinoma (HCC). A recent paper describes how VEGF-A stimulates paracrine secretion of hepatocyte growth factor by stromal cells, which induces tumor progression. HCC patients with VEGFA amplification are distin...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071286/ https://ncbi.nlm.nih.gov/pubmed/24823635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.019 |
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