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Probabilistic PCA of censored data: accounting for uncertainties in the visualization of high-throughput single-cell qPCR data

Motivation: High-throughput single-cell quantitative real-time polymerase chain reaction (qPCR) is a promising technique allowing for new insights in complex cellular processes. However, the PCR reaction can be detected only up to a certain detection limit, whereas failed reactions could be due to l...

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Main Authors: Buettner, Florian, Moignard, Victoria, Göttgens, Berthold, Theis, Fabian J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071202/
https://ncbi.nlm.nih.gov/pubmed/24618470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu134
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