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Practical Considerations for Dose Selection in Pediatric Patients to Ensure Target Exposure Requirements
Pediatric dosing recommendations are often not based on allometry, despite recognition that metabolic processes in mammals scale to the ¾ power. This report reviews the allometric size model for clearance and its implications for defining doses for children while considering practical limitations. F...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070253/ https://ncbi.nlm.nih.gov/pubmed/24841797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9603-x |
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