GNAS Gene Variants Affect β-blocker–related Survival after Coronary Artery Bypass Grafting

BACKGROUND: Cardiac overexpression of the β-adrenoreceptor (βAR)–coupled stimulatory G-protein subunit Gαs enhances inotropic responses to adrenergic stimulation and improves survival in mice under βAR blockade. The authors recently identified three common haplotypes in the GNAS gene encoding Gαs, w...

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Main Authors: Frey, Ulrich H., Muehlschlegel, Jochen D., Ochterbeck, Christoph, Fox, Amanda A., Shernan, Stanton K., Collard, Charles D., Lichtner, Peter, Peters, Jürgen, Body, Simon
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070180/
https://ncbi.nlm.nih.gov/pubmed/24755784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000189
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