Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of ‘oral’ exposures. It is now widely used – and in some cases required – by US federal agencies to assess potential toxicity of endocrine disrupting chemicals (EDCs). In this review we e...

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Bibliografiske detaljer
Main Authors: Vandenberg, Laura N, Welshons, Wade V, vom Saal, Frederick S, Toutain, Pierre-Louis, Myers, John Peterson
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Commentary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069342/
https://ncbi.nlm.nih.gov/pubmed/24961440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-069X-13-46
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