The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance in Mice by Restoring Hyperoxia-Compromised Macrophage Function

Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, prolonged exposure to hyperoxia compromises the ability of the macrophage to phagocytose and clear bacteria. Previously, we showed that the expo...

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Autores principales: Sitapara, Ravikumar A, Antoine, Daniel J, Sharma, Lokesh, Patel, Vivek S, Ashby, Charles R, Gorasiya, Samir, Yang, Huan, Zur, Michelle, Mantell, Lin L
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069272/
https://ncbi.nlm.nih.gov/pubmed/24664237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00086
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