Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways a...

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Hauptverfasser: Emran, Sahar, Yang, Mingyao, He, Xiaoli, Zandveld, Jelle, Piper, Matthew D. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069266/
https://ncbi.nlm.nih.gov/pubmed/24861087
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