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Computational Design of a pH Stable Enzyme: Understanding Molecular Mechanism of Penicillin Acylase's Adaptation to Alkaline Conditions

Protein stability provides advantageous development of novel properties and can be crucial in affording tolerance to mutations that introduce functionally preferential phenotypes. Consequently, understanding the determining factors for protein stability is important for the study of structure-functi...

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Bibliografische gegevens
Hoofdauteurs: Suplatov, Dmitry, Panin, Nikolay, Kirilin, Evgeny, Shcherbakova, Tatyana, Kudryavtsev, Pavel, Švedas, Vytas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069103/
https://ncbi.nlm.nih.gov/pubmed/24959852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100643
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