Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model

The aberrant fibrotic and repair responses in the lung are major hallmarks of idiopathic pulmonary fibrosis (IPF). Numerous antifibrotic strategies have been used in the clinic with limited success, raising the possibility that an effective therapeutic strategy in this disease must inhibit fibrosis...

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Détails bibliographiques
Auteurs principaux: Murray, Lynne A., Zhang, Huilan, Oak, Sameer R., Coelho, Ana Lucia, Herath, Athula, Flaherty, Kevin R., Lee, Joyce, Bell, Matt, Knight, Darryl A., Martinez, Fernando J., Sleeman, Matthew A., Herzog, Erica L., Hogaboam, Cory M.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068948/
https://ncbi.nlm.nih.gov/pubmed/24325475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0342OC
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