DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

DNA methylation is an epigenetic modification that is highly disrupted in response to cigarette smoke and involved in a wide spectrum of malignant and nonmalignant diseases, but surprisingly not previously assessed in small airways of patients with chronic obstructive pulmonary disease (COPD). Small...

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Autores principales: Vucic, Emily A., Chari, Raj, Thu, Kelsie L., Wilson, Ian M., Cotton, Allison M., Kennett, Jennifer Y., Zhang, May, Lonergan, Kim M., Steiling, Katrina, Brown, Carolyn J., McWilliams, Annette, Ohtani, Keishi, Lenburg, Marc E., Sin, Don D., Spira, Avrum, MacAulay, Calum E., Lam, Stephen, Lam, Wan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2014
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068945/
https://ncbi.nlm.nih.gov/pubmed/24298892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0304OC
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