Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC

We compared the dynamics and mechanisms of resistance development to ceftazidime, meropenem, ciprofloxacin, and ceftolozane-tazobactam in wild-type (PAO1) and mutator (PAOMS, ΔmutS) P. aeruginosa. The strains were incubated for 24 h with 0.5 to 64× MICs of each antibiotic in triplicate experiments....

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Bibliographic Details
Main Authors:	Cabot, Gabriel, Bruchmann, Sebastian, Mulet, Xavier, Zamorano, Laura, Moyà, Bartolomé, Juan, Carlos, Haussler, Susanne, Oliver, Antonio
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2014
Subjects:	Mechanisms of Resistance
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4068469/ https://ncbi.nlm.nih.gov/pubmed/24637685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02462-13
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Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC

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