Chimeric Na+/H+ exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases.

Eitemau Tebyg

• Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.
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• Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor
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• Membrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain
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  Cyhoeddwyd: (2011)
• cAMP-mediated inhibition of the epithelial brush border Na(+)/H(+) exchanger, NHE3, requires an associated regulatory protein
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• Cell Shape Regulation by Gravin Requires N-terminal Membrane Effector Domains
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