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Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics
BACKGROUND IMPORTANCE OF THE FIELD: Therapeutic proteins and DNA constructs offer promise for the treatment of central nervous system disorders, yet significant biological barriers limit the ability of these molecules to reach the central nervous system from the bloodstream. Direct administrations t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068128/ https://ncbi.nlm.nih.gov/pubmed/20201735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425240903540205 |
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