Identification of a Functional TPH1 Polymorphism Associated with Irritable Bowel Syndrome Bowel Habit Subtypes

BACKGROUND & AIMS: Alterations in 5-hydroxytryptamine (5-HT) signaling have been implicated as a factor contributing to the altered bowel habit of irritable bowel syndrome (IBS) patients. Tryptophan hydroxylase 1 (TPH1) is the rate–limiting enzyme in enterochromaffin cell 5-HT biosynthesis. We h...

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Main Authors: Grasberger, Helmut, Chang, Lin, Shih, Wendy, Presson, Angela P., Sayuk, Gregory S., Newberry, Rodney D., Karagiannides, Iordanis, Pothoulakis, Charalabos, Mayer, Emeran, Merchant, Juanita L.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067697/
https://ncbi.nlm.nih.gov/pubmed/24060757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2013.304
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