Spinal 5-HT(3) receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade

BACKGROUND: It has been recently recognized that the descending serotonin (5-HT) system from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT(3) receptor subtype in the spinal dorsal horn are involved in enhanced descending pain facilitation after tissue and nerve injury. However...

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Autors principals: Guo, Wei, Miyoshi, Kan, Dubner, Ronald, Gu, Ming, Li, Man, Liu, Jian, Yang, Jiale, Zou, Shiping, Ren, Ke, Noguchi, Koichi, Wei, Feng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067691/
https://ncbi.nlm.nih.gov/pubmed/24913307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-35
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