Microinjection free delivery of miRNA inhibitor into zygotes

The development of gene delivery systems into embryos is challenging due to technical difficulties, delivery efficiency and toxicity. Here, we developed an organic compound (VisuFect)-mediated gene delivery system for zygotes. The VisuFect, which is hydrophilic and Cy5.5-labeled, was conjugated with...

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Detalhes bibliográficos
Main Authors: Joo, Jin Young, Lee, Jonghwan, Ko, Hae Young, Lee, Yong Seung, Lim, Do-Hwan, Kim, Eun-Young, Cho, Sujeong, Hong, Ki-Sung, Ko, Jung Jae, Lee, Suman, Lee, Young Sik, Choi, Youngsok, Lee, Kyung-Ah, Kim, Soonhag
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067617/
https://ncbi.nlm.nih.gov/pubmed/24957209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05417
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