The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

Chemotherapy-induced peripheral neuropathy (CIPN) characterized by loss of sensory sensitivity and pain in hands and feet is the major dose-limiting toxicity of many chemotherapeutics. At present, there are no FDA-approved treatments for CIPN. The anti-diabetic drug metformin is the most widely used...

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Detalhes bibliográficos
Main Authors: Mao-Ying, Qi-Liang, Kavelaars, Annemieke, Krukowski, Karen, Huo, Xiao-Jiao, Zhou, Wenjun, Price, Theodore J., Cleeland, Charles, Heijnen, Cobi J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067328/
https://ncbi.nlm.nih.gov/pubmed/24955774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100701
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