Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury

The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+)...

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Hauptverfasser: Mardaryev, Andrei N., Meier, Natalia, Poterlowicz, Krzysztof, Sharov, Andrey A., Sharova, Tatyana Y., Ahmed, Mohammed I., Rapisarda, Valentina, Lewis, Christopher, Fessing, Michael Y., Ruenger, Thomas M., Bhawan, Jag, Werner, Sabine, Paus, Ralf, Botchkarev, Vladimir A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2011
Schlagworte:
Development and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067271/
https://ncbi.nlm.nih.gov/pubmed/22028024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.070284
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