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Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability

The role of programmed cell death 4 (PDCD4) in tumor biology is context-dependent. PDCD4 is described as a tumor suppressor, but its coexpression with protein arginine methyltransferase 5 (PRMT5) promotes accelerated tumor growth. Here, we report that PDCD4 is methylated during nutrient deprivation....

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Bibliografiske detaljer
Main Authors: Fay, Marta M., Clegg, James M., Uchida, Kimberly A., Powers, Matthew A., Ullman, Katharine S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067190/
https://ncbi.nlm.nih.gov/pubmed/24764298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541300
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