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Correlation of Structure and Function in the Human Hotdog-fold Enzyme hTHEM4
Human THEM4 (hTHEM4) is comprised of a catalytically active hotdog-fold acyl-CoA thioesterase domain and an N-terminal domain of unknown fold and function. hTHEM4 has been linked to Akt1 regulation and cell apoptosis. Herein, we report the X-ray structure of hHTEM4 bound with undecan-2-one-CoA. Stru...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066673/ https://ncbi.nlm.nih.gov/pubmed/22871024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300968n |
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