Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.

The RII beta regulatory subunit of cAMP-dependent protein kinase (PKA) contains an autophosphorylation site and a nuclear location signal, KKRK. We approached the structure-function analysis of RII beta by using site-directed mutagenesis. Ser114 (the autophosphorylation site) of human RII beta was r...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Budillon, A, Cereseto, A, Kondrashin, A, Nesterova, M, Merlo, G, Clair, T, Cho-Chung, Y S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479855/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.23.10634
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