Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear. Via a quantitative proteomics approach using the model organism Caenorhabditis elegans, we gained molecular unde...

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Autors principals: De Haes, Wouter, Frooninckx, Lotte, Van Assche, Roel, Smolders, Arne, Depuydt, Geert, Billen, Johan, Braeckman, Bart P., Schoofs, Liliane, Temmerman, Liesbet
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066537/
https://ncbi.nlm.nih.gov/pubmed/24889636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321776111
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