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Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei

African trypanosomes survive the immune defense of their hosts by regularly changing their antigenic coat made of variant surface glycoprotein (VSG). The Trypanosoma brucei genome contains more than 1,000 VSG genes. To be expressed, a given VSG gene must be located in one of 15 telomeric regions ter...

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Detalles Bibliográficos
Main Authors: Kassem, Ali, Pays, Etienne, Vanhamme, Luc
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066500/
https://ncbi.nlm.nih.gov/pubmed/24889641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404873111
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