Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.

Microsomal cytochrome P450c17 catalyzes both steroid 17 alpha-hydroxylase activity and scission of the C17-C20 steroid bond (17,20-lyase) on the same active site. Adrenal 17 alpha-hydroxylase activity is needed to produce cortisol throughout life, but 17,20-lyase activity appears to be controlled in...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Zhang, L H, Rodriguez, H, Ohno, S, Miller, W L
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.23.10619
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