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Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system
Introducing a point mutation is a fundamental method used to demonstrate the roles of particular nucleotides or amino acids in the genetic elements or proteins, and is widely used in in vitro experiments based on cultured cells and exogenously provided DNA. However, the in vivo application of this a...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066261/ https://ncbi.nlm.nih.gov/pubmed/24953798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05396 |
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