TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates t...

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Autori principali: Angiari, Stefano, Donnarumma, Tiziano, Rossi, Barbara, Dusi, Silvia, Pietronigro, Enrica, Zenaro, Elena, Della Bianca, Vittorina, Toffali, Lara, Piacentino, Gennj, Budui, Simona, Rennert, Paul, Xiao, Sheng, Laudanna, Carlo, Casasnovas, Jose M., Kuchroo, Vijay K., Constantin, Gabriela
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066214/
https://ncbi.nlm.nih.gov/pubmed/24703780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.004
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