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Synthetically Modified l-Histidine-Rich Peptidomimetics Exhibit Potent Activity Against Cryptococcus neoformans

We describe the synthesis and antimicrobial evaluation of structurally new peptidomimetics, rich in synthetically modified l-histidine. Two series of tripeptidomimetics were synthesized by varying lipophilicity at the C-2 position of l-histidine and at the N- and C-terminus. The data indicates that...

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Hlavní autoři: Mahindra, Amit, Bagra, Nitin, Wangoo, Nishima, Jain, Rohan, Khan, Shabana. I., Jacob, Melissa R., Jain, Rahul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065882/
https://ncbi.nlm.nih.gov/pubmed/24878194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.04.120
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