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The combined role of galactose-deficient IgA(1)and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy
IgA nephropathy is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA(1) and C3. We have previously shown that IgA-binding regions of streptococcal M proteins co-localize with IgA in mesangi...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4065838/ https://ncbi.nlm.nih.gov/pubmed/24850720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302249 |
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