Do the dissociative side effects of ketamine mediate its antidepressant effects?

BACKGROUND: The N-methyl-D-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy. ME...

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Autors principals: Luckenbaugh, David A., Niciu, Mark J., Ionescu, Dawn F., Nolan, Neal M., Richards, Erica M., Brutsche, Nancy E., Guevara, Sara, Zarate, Carlos A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065787/
https://ncbi.nlm.nih.gov/pubmed/24679390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jad.2014.02.017
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