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Assessment and refinement of eukaryotic gene structure prediction with gene-structure-aware multiple protein sequence alignment

BACKGROUND: Accurate computational identification of eukaryotic gene organization is a long-standing problem. Despite the fundamental importance of precise annotation of genes encoded in newly sequenced genomes, the accuracy of predicted gene structures has not been critically evaluated, mostly due...

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Main Authors: Gotoh, Osamu, Morita, Mariko, Nelson, David R
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065584/
https://ncbi.nlm.nih.gov/pubmed/24927652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-189
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