Modeling and Estimation of Kinetic Parameters and Replicative Fitness of HIV-1 from Flow-Cytometry-Based Growth Competition Experiments

Growth competition assays have been developed to quantify the relative fitness of HIV-1 mutants. In this article, we develop mathematical models to describe viral/cellular dynamic interactions in the assay system from which the competitive fitness indices or parameters are defined. In our previous H...

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Detalhes bibliográficos
Main Authors: Miao, Hongyu, Dykes, Carrie, Demeter, Lisa M., Cavenaugh, James, Park, Sung Yong, Perelson, Alan S., Wu, Hulin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065495/
https://ncbi.nlm.nih.gov/pubmed/18648886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11538-008-9323-4
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