Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer

The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR). AR protein levels are controlled by the AR-PMEPA1 negative feedback loop through NEDD4-E3 ligase. Reduced expres...

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Hlavní autoři: Sharad, Shashwat, Ravindranath, Lakshmi, Haffner, Michael C, Li, Hua, Yan, Wusheng, Sesterhenn, Isabell A, Chen, Yongmei, Ali, Amina, Srinivasan, Alagarsamy, McLeod, David G, Yegnasubramanian, Srinivasan, Srivastava, Shiv, Dobi, Albert, Petrovics, Gyorgy
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065188/
https://ncbi.nlm.nih.gov/pubmed/24694733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.28710
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