DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations

Ectrodactyly, or Split-Hand/Foot Malformation (SHFM), is a congenital condition characterized by the loss of central rays of hands and feet. The p63 and the DLX5;DLX6 transcription factors, expressed in the embryonic limb buds and ectoderm, are disease genes for these conditions. Mutations of p63 al...

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Autori principali: Restelli, Michela, Lopardo, Teresa, Lo Iacono, Nadia, Garaffo, Giulia, Conte, Daniele, Rustighi, Alessandra, Napoli, Marco, Del Sal, Giannino, Perez-Morga, David, Costanzo, Antonio, Merlo, Giorgio Roberto, Guerrini, Luisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065156/
https://ncbi.nlm.nih.gov/pubmed/24569166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu096
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