Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mechanisms remain unclear. We explored roles for astrocytes, which display mutant huntingtin in HD patients and mouse models. We found that symptom onset in R6/2 and Q175 HD mouse mo...

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Autores principales: Tong, Xiaoping, Ao, Yan, Faas, Guido C., Nwaobi, Sinifunanya E., Xu, Ji, Haustein, Martin D., Anderson, Mark A., Mody, Istvan, Olsen, Michelle L., Sofroniew, Michael V., Khakh, Baljit S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064471/
https://ncbi.nlm.nih.gov/pubmed/24686787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3691
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