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Cytosolic Ca(2+) prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca(2+) overload
The stromal interacting molecule (STIM1) is pivotal for store-operated Ca(2+) entry (SOC). STIM1 proteins sense the Ca(2+) concentration within the lumen of the endoplasmic reticulum (ER) via an EF-hand domain. Dissociation of Ca(2+) from this domain allows fast oligomerization of STIM1 and the form...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4064434/ https://ncbi.nlm.nih.gov/pubmed/18765567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.034496 |
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